Comprehensive NAG Support for Better Joint Health
As joint health issues continue to affect millions globally, TCI is introducing the N-acetylglucosamine (NAG) solution. Backed by science, this supplement is designed for anyone looking to maintain or improve joint function, from active individuals to those dealing with age-related joint concerns such as osteoarthritis.
Highly Bioavailable N-Acetylglucosamine
N-Acetylglucosamine (NAG) is a critical building block of essential polysaccharides in the body. It is particularly abundant in the exoskeletons of shellfish and is known for its anti-inflammatory and antioxidant properties. In joint health, NAG promotes the synthesis of hyaluronic acid, a vital component in cartilage and joint lubrication, by upregulating hyaluronan synthase-2 in chondrocytes. [1] By enhancing hyaluronic acid production, NAG supports cartilage metabolism, helping to prevent cartilage breakdown and reduce joint discomforts. [2,3]
Studies have shown that NAG is a highly bioavailable form of glucosamine, with up to three times the bioavailability of regular glucosamine. [4] This improved absorption allows for a lower 300 mg daily dose while still providing significant benefits.
Reduce Cartilage Degradation, Inhibit Inflammation, Move Better
A 16-week randomized, double-blind trial involving 65 participants found that daily doses of NAG at 500 mg or 1000 mg reduced cartilage breakdown and supported joint health. This was evidenced by a significant decrease in the C2C/PIICP type II collagen degradation-to-synthesis ratio. [5]
Furthermore, NAG provides anti-inflammatory benefits by inhibiting IL-1β- and TNF-α-induced nitric oxide (NO) production in human articular chondrocytes, which contributes to reduced swelling and stiffness. [6] In a separate study, osteoarthritis patients reported significant improvements in joint comfort and mobility after just four weeks of daily intake, with both the 500 mg and 1000 mg doses showing reductions in pain and enhanced mobility. [4]
TCI’s NAG formulation also addresses age-related joint degradation, a common issue in older adults. As cartilage deteriorates, it leads to pain, inflammation, and restricted movement. The formulation works to alleviate these symptoms by strengthening cartilage, reducing inflammation, and slowing the progression of joint degradation.
TCI’s Exclusive Joint Health and Wellness Solution
Beyond NAG’s remarkable benefits, TCI’s formulation includes a blend of supporting ingredients known for their anti-inflammatory and joint-supporting properties. The solution also incorporates ingredients such as Dr. Lu® Lates calcarifer extract and curcumin, creating a three-step approach to joint care: muscle recovery, inflammation reduction, and cartilage support. [7] Furthermore, the benefits of NAG may be further enhanced when combined with TCI633 probiotics, small molecular collagen, and advanced Double Nutri® liposomal technology. Together, these ingredients provide comprehensive joint protection and support overall wellness with just one convenient daily serving.
This advanced joint-care solution is produced using proprietary extraction and formulation techniques, ensuring maximum efficacy and bioavailability. The NAG formula is designed to provide optimal joint support while minimizing potential side effects associated with high doses of glucosamine-based supplements.
- Tomonaga, A., Watanabe, K., Fukagawa, M., Suzuki, A., Kurokawa, M., & Nagaoka, I. (2016). Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals without symptoms of arthritis: A randomized double‑blind placebo‑controlled clinical study. Experimental and Therapeutic Medicine, 12(3), 1481-1489.
- Shikhman, A. R., Brinson, D. C., Valbracht, J., & Lotz, M. K. (2009). Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes. Osteoarthritis and Cartilage, 17(8), 1022-1028.
- Kubomura, D., Ueno, T., Yamada, M., Tomonaga, A., & Nagaoka, I. (2017). Effect of N-acetylglucosamine administration on cartilage metabolism and safety in healthy subjects without symptoms of arthritis: A case report. Experimental and therapeutic medicine, 13(4), 1614–1621.
- 梶本修身. (2003). 天然型 N-アセチルグルコサミン含有ミルクの変形性膝関節症に対する治療効果. 新薬と臨牀, 52, 301-312.
- Tomonaga, A., Watanabe, K., Fukagawa, M., Suzuki, A., Kurokawa, M., & Nagaoka, I. (2016). Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals without symptoms of arthritis: A randomized double-blind placebo-controlled clinical study. Experimental and therapeutic medicine, 12(3), 1481–1489. https://doi.org/10.3892/etm.2016.3480
- Shikhman, A. R., Kuhn, K., Alaaeddine, N., & Lotz, M. (2001). N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes. Journal of Immunology (Baltimore, Md. : 1950), 166(8), 5155–5160.
- Chotphruethipong, L., Sukketsiri, W., Aluko, R. E., Sae-Leaw, T., & Benjakul, S. (2021). Effect of hydrolyzed collagen from defatted Asian sea bass (Lates calcarifer) skin on fibroblast proliferation, migration and antioxidant activities. Journal of Food Science and Technology, 58, 541-551.
GLOBAL TOTAL SOLUTION
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